ESPE Abstracts

Background: Hypophosphatasia (HP) is a rare inherited disorder characterized by defective bone and tooth mineralization and caused by deficiency in the tissue non-specific alkaline phosphatase gene (ALPL). The symptoms are remarkably variable in their clinical expression, and relate to numerous mutations in this gene.Aim: The purpose of this study was to document the clinical, biochemical and radiologic aspects of the th...

Objective: Dental plaque removal is an important factor in preventing periodontal diseases and caries. Tooth brushing remains the most reliable method of controlling dental plaque. The purpose of this study was to compare the effectiveness of plaque control performed with a battery powered and manual toothbrushes in over-weight adolescents.Materials and methods: The twenty two adolesents with over-weight were attended in this study. These patients were d...

Background: Adipose tissue acts as an endocrine organ, secreting biologically active molecules in response to external stimuli or lipid overloading. These adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin (4). On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between weight gain and serum...

Background: The exact mechanisms on growth are not fully eluciated, but they involve insulin resistance, fetal hyperleptinemia, hypothalamic changes. The adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin. On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between growth and serum insulin, ...

Introduction: Growth hormone (hGH) and/or growth factors are thought to play a role in the pathogenesis of diabetic retinopathy. Increased treatment of human growth hormone (hGH) in children rise questions concerning the safety of GH replacement therapy on ophtalmic changes. Adverse effects of hGH treatment (pseudotumor cerebri, papilloedema, retinal changes mimicking diabetic retinopathy, neovascularization) have been reported in some papers. In this study, i...

Background: Hypercalcaemia is caused by many different conditions. Vitamin D intoxication with severe hypercalcemia is rare in the neonatal and infancy period. Here we described a 4-month-old male with severe hypercalcemia secondary to taking oral 600 000 units of vitamin D. He was diagnosed vitamin D 24-hydroxylase gene (CYP24A1) mutation after evaluation.Case presentatıon: He was admitted to our hospital with high serum calcium level (23 mg/dl). S...

Introduction: The hypothalamo-pituitary system is activated as puberty begins and GnRH release occurs as well as the synthesis of many hormones. These hormones cause changes on muscle development, body fat distribution. In this study, changes in miyostatin, irisin, kisspeptin, omentin and leptin levels and the relationship of these changes with physical properties and fat tissue were investigated.Material and Method: A t...

Introduction & Objectives: High consumption of processed foods rich in fat and sugar are associated with the increasing prevalence of metabolic disturbances like obesity, insülin resistance, dyslipidemia, type 2 diabetes mellitus. In the present study, we aimed to investigate the relationship between advanced glycation end products and metabolic disorders such as insulin resistance caused by high fructose and high-fat diet, and also examine histologic...

Aim: The pathophysiology of developing hypophosphatemia in children with diabetic ketoacidosis (DKA) has not been sufficiently elucidated. Fibroblast Growth Factor 23 (FGF23) is a hormone that causes phosphate excretion from the kidneys. The increase of FGF23 in children with DKA may explain the pathophysiology of hypophosphatemia in these children. The aim of our study was to investigate the effect of serum FGF23 on serum phosphorus level in children with DKA...

Aim: To investigate the prevalence of hirsutism among adolescents using the modified Ferriman-Gallway (FG) Scale and to determine etiological factors in childen with hirsutism.Materials and methods: The study was in 2380 female adolescents aged 12–18 years. The modified FG score was used in the diagnosis and monitoring of hirsutism. Scores of 8 or above were regarded as hirsutism. Two hundred thirty-three volunteers determined as having hirsutism we...